Which of the following histone modifications is generally associated with opening chromatin and activating transcription?
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Correct answer: Histone acetylation (e.g., H3 acetyl-lysine)
Histone acetylation neutralizes positive charges on histones, reduces histone-DNA interaction, de-condenses chromatin (euchromatin), and thereby facilitates transcription activation.
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More Gene Regulation and Epigenetics questions
- Which histone modification is often correlated with transcriptional repression and formation of heterochromatin?
- Which non–DNA-altering mechanism can regulate gene expression post-transcriptionally in epigenetic control?
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