Which enzyme joins Okazaki fragments on the lagging strand to create a continuous DNA strand?
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Correct answer: DNA ligase
DNA ligase seals the sugar–phosphate backbone by forming phosphodiester bonds between adjacent Okazaki fragments, producing a continuous lagging strand.
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More DNA Structure and Replication questions
- Which of the following proteins stabilize single-stranded DNA during replication to prevent re-annealing or degradation?
- What is the role of topoisomerase (or DNA gyrase in prokaryotes) during DNA replication?
- Which DNA polymerase performs the bulk of leading-strand synthesis in prokaryotes during replication?
- Which of the following correctly describes the directionality of new DNA strand synthesis by DNA polymerase?
- Why are Okazaki fragments necessary on the lagging strand during DNA replication?
- Which component forms the “replisome” complex at the replication fork in prokaryotes?