DNA Structure and Replication · USMLE Step 1

Which DNA polymerase performs the bulk of leading-strand synthesis in prokaryotes during replication?

  1. DNA polymerase I
  2. DNA polymerase II
  3. DNA polymerase III
  4. DNA polymerase IV
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Correct answer: DNA polymerase III

In prokaryotes, DNA polymerase III is the main enzyme that synthesizes new DNA strands (both leading and lagging) during replication.

Difficulty: Medium Question 8 of 20

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