In the Phospholipase C (PLC) signaling pathway, which molecule is responsible for directly triggering the release of calcium from the endoplasmic reticulum?
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Correct answer: Inositol trisphosphate (IP3)
PLC cleaves membrane phospholipids into DAG and IP3. While DAG remains in the membrane to activate PKC, IP3 diffuses into the cytosol and binds to ligand-gated calcium channels on the ER.
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