Which of the following hormones utilizes a mechanism involving the JAK-STAT pathway rather than intrinsic tyrosine kinase activity?
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Correct answer: Growth Hormone
The Growth Hormone receptor lacks intrinsic kinase activity but instead recruits Janus Kinases (JAKs) upon binding. These kinases then phosphorylate Signal Transducers and Activators of Transcription (STATs) to regulate gene expression.
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