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Hormone Classification and Mechanisms · Physiology

What determines the 'metabolic clearance rate' of a hormone in the circulation?

  1. The rate of hormone secretion into the circulation
  2. The affinity of the hormone for its target receptor
  3. The degree of protein binding and rate of degradation
  4. The number of second messengers activated per hormone
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Correct answer: The degree of protein binding and rate of degradation

Hormones that are highly bound to plasma proteins have a lower metabolic clearance rate and a longer half-life. Clearance is primarily achieved through enzymatic degradation in the liver and excretion by the kidneys.

Difficulty: Medium Question 29 of 40

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