Hormone Classification and Mechanisms · Physiology

Which enzyme is responsible for the termination of the second messenger signal produced by Adenylyl Cyclase?

  1. Phosphodiesterase (PDE)
  2. Protein Kinase A (PKA)
  3. Phospholipase A2 (PLA2)
  4. GTPase activating protein
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Correct answer: Phosphodiesterase (PDE)

Adenylyl cyclase produces cAMP, which activates PKA. Phosphodiesterase breaks down cAMP into 5'-AMP, effectively ending the intracellular signal and preventing overstimulation of the target cell.

Difficulty: Medium Question 26 of 40

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