A patient taking Digoxin is started on Hydrochlorothiazide. What is the primary concern for this drug combination?
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Correct answer: Hypokalemia caused by thiazides increases Digoxin toxicity risk
Digoxin binds to the Na+/K+ ATPase pump by competing with potassium. Low serum potassium levels (hypokalemia) induced by thiazides allow for increased Digoxin binding, which can lead to life-threatening arrhythmias.
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