Loop diuretics can lead to hyperuricemia and potentially precipitate a gout attack because they:
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Correct answer: Compete with uric acid for the organic acid transporter
Loop diuretics are secreted into the proximal tubule by the organic acid secretory system. They compete with uric acid for this transporter and cause volume depletion, which enhances proximal tubule reabsorption of uric acid.
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More Loop Diuretics questions
- Which of the following clinical conditions is an acute indication for the use of intravenous Furosemide?
- A patient presents with muscle weakness and an EKG showing U-waves. Which electrolyte abnormality caused by loop diuretics is most likely?
- Which loop diuretic has the longest half-life and the highest oral bioavailability?
- Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the diuretic effect of Furosemide by inhibiting the synthesis of:
- What is the primary site of action for loop diuretics within the nephron?
- Which of the following is a potential endocrine side effect of chronic loop diuretic therapy?