Loop diuretics are known to decrease the reabsorption of which divalent cations by abolishing the lumen-positive transepithelial potential?
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Correct answer: Magnesium and Calcium
The inhibition of NKCC2 stops the back-diffusion of K+ into the lumen, which normally creates a positive charge that drives the paracellular reabsorption of Ca2+ and Mg2+. Consequently, loop diuretics increase the urinary excretion of both magnesium and calcium.
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