Which of the following describes the primary mechanism of action of Cyclosporine?
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Correct answer: Binding to cyclophilin to inhibit calcineurin
Cyclosporine forms a complex with the intracellular protein cyclophilin. This complex inhibits calcineurin, a phosphatase required for the translocation of NFAT to the nucleus, thereby preventing the transcription of IL-2.
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More Immunosuppressants questions
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