Sirolimus (Rapamycin) differs from Tacrolimus because it inhibits which signaling pathway?
Show answer and explanation
Correct answer: mTOR (mammalian Target of Rapamycin)
While Sirolimus binds to FKBP-12 like tacrolimus, it does not inhibit calcineurin. Instead, it inhibits the mTOR kinase, which blocks the response to IL-2 rather than its production.
Keep practicing
More Immunosuppressants questions
- Azathioprine is a prodrug that is converted into which active metabolite?
- A dangerous drug interaction occurs when Azathioprine is administered with which medication, leading to bone marrow suppression?
- Which side effect is commonly associated with Sirolimus but rarely seen with Calcineurin inhibitors?
- Glucocorticoids suppress the immune response primarily by:
- Which of the following is a monoclonal antibody that blocks the IL-2 receptor (CD25) on activated T-cells?
- Which immunosuppressant is an alkylating agent often used for severe systemic lupus erythematosus or as a rescue therapy in organ rejection?