What is the most characteristic and dose-limiting toxicity associated with the long-term use of Tacrolimus and Cyclosporine?
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Correct answer: Nephrotoxicity
Both calcineurin inhibitors (CNIs) cause renal vasoconstriction and chronic interstitial fibrosis. Monitoring of serum creatinine and drug levels is essential to balance immunosuppression with the risk of kidney damage.
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More Immunosuppressants questions
- Tacrolimus exerts its effect by binding to which specific immunophilin?
- Which immunosuppressant inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH)?
- Sirolimus (Rapamycin) differs from Tacrolimus because it inhibits which signaling pathway?
- Azathioprine is a prodrug that is converted into which active metabolite?
- A dangerous drug interaction occurs when Azathioprine is administered with which medication, leading to bone marrow suppression?
- Which side effect is commonly associated with Sirolimus but rarely seen with Calcineurin inhibitors?