A drug has a Volume of Distribution (Vd) of 500 Liters in a 70kg patient. What does this indicate about the drug's distribution?
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Correct answer: The drug is likely sequestered in peripheral tissues or fat
A volume of distribution that exceeds total body water (approximately 42L) suggests that the drug is extensively distributed into tissues. Such high values often indicate high lipid solubility or extensive tissue binding.
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