Which of the following factors will increase the half-life of a drug that is primarily eliminated by the kidneys?
Show answer and explanation
Correct answer: Renal failure or decreased creatinine clearance
Half-life is inversely proportional to clearance; therefore, a decrease in renal clearance due to kidney failure will result in a prolonged half-life. This often necessitates dose adjustments to avoid toxicity.
Keep practicing
More Pharmacokinetics questions
- A loading dose is primarily calculated based on which pharmacokinetic parameter?
- Which of the following describes a 'Prodrug'?
- What is the primary site of drug absorption for most oral medications?
- Acidification of urine would most likely accelerate the excretion of which type of drug?
- Which plasma protein is the most important for the binding of acidic drugs?
- If a drug follows first-order kinetics, what happens to the rate of elimination as the plasma concentration increases?