The Henderson-Hasselbalch equation is clinically useful for predicting which process?
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Correct answer: The pH-dependent ionization and 'trapping' of drugs across membranes
The equation helps determine the ratio of ionized to non-ionized drug forms at a specific pH. Weak acids become trapped in alkaline environments (like urine) because they become ionized and cannot easily diffuse back across lipid membranes.
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