In a patient with a Creatinine Clearance of 15 mL/min, what adjustment is usually required for drugs primarily excreted by the kidneys?
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Correct answer: Reduce the dose or lengthen the dosing interval to avoid accumulation
Reduced renal function (low GFR) means the body cannot clear drugs as quickly. To avoid toxic accumulation, the total daily dose must be decreased by either reducing the individual doses or spacing them further apart.
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