What is 'Total Body Clearance' ($Cl_{total}$)?
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Correct answer: The volume of plasma cleared of drug per unit time by all eliminating organs
Total body clearance is the sum of clearances from various organs, primarily the liver (hepatic clearance) and the kidneys (renal clearance). It is a vital parameter for determining the maintenance dose of a drug.
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More Drug Excretion questions
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- What is the primary organ responsible for the excretion of most water-soluble drugs and their metabolites?