Which measure is the most common clinical estimate of a patient's Glomerular Filtration Rate (GFR)?
Show answer and explanation
Correct answer: Creatinine clearance
Creatinine is an endogenous byproduct of muscle metabolism that is filtered by the glomerulus with minimal secretion or reabsorption. Measuring its clearance provides a reliable proxy for the actual GFR of the kidneys.
Keep practicing
More Drug Excretion questions
- For a drug that follows 'First-Order Kinetics', what happens to the amount of drug eliminated per hour if the plasma concentration doubles?
- Why are neonates (newborns) at a higher risk of drug toxicity for medications excreted by the kidneys?
- Besides urine and bile, heavy metals such as mercury or lead are notably eliminated through which route?
- What is the primary organ responsible for the excretion of most water-soluble drugs and their metabolites?
- Which renal process passively removes small, unbound drug molecules from the plasma at the start of the nephron?
- How does the ionization of a weak acid drug (e.g., Aspirin) in alkaline urine affect its renal excretion?