What is the primary role of P-glycoprotein in the blood-brain barrier?
Show answer and explanation
Correct answer: To pump drugs out of the brain into the blood
P-glycoprotein is an ATP-dependent efflux pump located in the brain capillary endothelium. It actively removes a wide variety of drugs from the CNS, even if they are lipophilic enough to have crossed the membrane.
Keep practicing
More Drug Distribution questions
- If a drug has a Volume of Distribution of 15 Liters, it is likely distributed in which body compartments?
- Which of the following describes the 'Volume of Distribution' (Vd) of a drug?
- Which plasma protein is the most significant binder for acidic drugs like Warfarin and Salicylates?
- A drug with an extremely high Volume of Distribution (Vd > 40 L/70kg) typically indicates that:
- Which anatomical barrier is characterized by tight junctions between endothelial cells and a lack of fenestrations, limiting drug entry int…
- What is the clinical significance of 'Displacement' in the context of plasma protein binding?