A drug with an extremely high Volume of Distribution (Vd > 40 L/70kg) typically indicates that:
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Correct answer: The drug is highly lipid-soluble and sequestered in tissues or fat
High Vd values suggest the drug has moved out of the plasma and into extravascular compartments like adipose tissue or intracellular fluid. This often occurs with highly lipophilic drugs that have low plasma protein binding.
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