What is the clinical significance of 'Displacement' in the context of plasma protein binding?
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Correct answer: Another drug displaces it from albumin, raising its free fraction and toxicity
If Drug A is highly bound to albumin and Drug B is added, Drug B may displace Drug A. This results in a sudden increase in the 'free' (active) concentration of Drug A, which may lead to toxic effects even if total drug levels remain unchanged.
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