Which of the following electrolytes is most commonly depleted with chronic, high-dose PPI therapy, potentially leading to tetany or arrhythmias?
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Correct answer: Magnesium
Chronic PPI use can lead to hypomagnesemia, likely due to interference with magnesium absorption in the intestine. This effect is rare but can be severe, requiring magnesium supplementation and discontinuation of the PPI.
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More Proton Pump Inhibitors questions
- PPIs may reduce the absorption of which vitamin that requires gastric acid for its release from dietary proteins?
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- Which of the following is an FDA-approved clinical indication for PPIs?
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