In the treatment of septic shock, 'stress-dose' hydrocortisone is used based on which clinical rationale?

1. To directly target and eliminate the Gram-negative bacteria responsible for causing the septic infection
2. To treat relative adrenal insufficiency and improve vascular responsiveness to catecholamines
3. To stimulate and significantly increase the overall production of white blood cells
4. To reduce and normalize the elevated body temperature seen in patients with septic shock

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