A patient on prednisone develops a gastric ulcer. What is the mechanism behind 'steroid-induced' peptic ulcer disease?
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Correct answer: Inhibition of prostaglandin synthesis which maintains the mucosal barrier
By inhibiting phospholipase A2 and COX enzymes, corticosteroids reduce the levels of cytoprotective prostaglandins (like PGE2) in the stomach. This thins the protective mucus layer, making the mucosa more vulnerable to acid.
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