Clinical Trials · Pharmacology

In a 'Crossover' study design, what happens to the participants?

  1. They are randomly assigned to either a treatment or control group for the entire duration
  2. They receive the experimental drug followed by a washout period, then receive the control/placebo
  3. They are followed prospectively to see if they develop a specific disease
  4. They are selected based on having a specific disease and compared to healthy controls
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Correct answer: They receive the experimental drug followed by a washout period, then receive the control/placebo

In a crossover trial, each subject acts as their own control by receiving both the test drug and the placebo at different times. This design requires a washout period to ensure the first treatment is cleared before the second begins.

Difficulty: Medium Question 6 of 20

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