Clinical Trials · Pharmacology

A Phase II clinical trial is best described by which of the following characteristics?

  1. Post-marketing surveillance of rare adverse effects
  2. Large-scale multicenter trials to confirm clinical benefit
  3. Exploratory study in a small number of patients with the target disease to evaluate efficacy
  4. Preclinical testing in animal models for teratogenicity
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Correct answer: Exploratory study in a small number of patients with the target disease to evaluate efficacy

Phase II trials focus on 'proof of concept' and finding the optimal dose in patients who actually have the disease. These studies help determine if the drug has enough biological activity to warrant expensive Phase III testing.

Difficulty: Medium Question 2 of 20

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