Which opioid has an extremely short half-life (approx. 3-4 minutes) because it is rapidly metabolized by non-specific tissue and plasma esterases?
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Correct answer: Remifentanil
Remifentanil is unique because its metabolism is independent of hepatic or renal function. Its rapid clearance allows for precise, minute-to-minute control during general anesthesia and immediate recovery after the infusion is stopped.
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