Mood Stabilizers · Pharmacology

What is the primary mechanism of action for Carbamazepine as a mood stabilizer?

  1. Inhibition of GABA transaminase
  2. Blockade of voltage-gated sodium channels
  3. Antagonism of NMDA glutamate receptors
  4. Binding to the alpha-2-delta subunit of calcium channels
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Correct answer: Blockade of voltage-gated sodium channels

Carbamazepine stabilizes hyper-excited nerve membranes by inhibiting voltage-gated sodium channels in their inactivated state. This reduces the propagation of abnormal electrical impulses in the brain.

Difficulty: Medium Question 11 of 20

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