A patient taking both Valproic acid and Lamotrigine is at a significantly higher risk for Stevens-Johnson syndrome because Valproic acid:
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Correct answer: Inhibits the glucuronidation of Lamotrigine
Valproic acid inhibits the metabolic pathway (glucuronidation) of Lamotrigine, doubling its half-life and serum concentration. When used together, the Lamotrigine dose must be reduced by at least 50%.
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