Local Anesthetics · Pharmacology

Which factor enhances the effectiveness of local anesthetics?

  1. Alkaline tissue environment
  2. Highly acidic tissue environment
  3. Increased tissue perfusion
  4. Low lipid solubility
Show answer and explanation

Correct answer: Alkaline tissue environment

Local anesthetics work best in slightly alkaline environments. In acidic tissues such as infected areas, their effectiveness is reduced because fewer molecules penetrate nerve membranes.

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