Local Anesthetics · Pharmacology

Which property of a local anesthetic influences its ability to penetrate nerve membranes?

  1. Protein binding
  2. Molecular weight
  3. Lipid solubility
  4. Plasma esterase activity
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Correct answer: Lipid solubility

Lipid solubility determines how easily a drug can cross nerve membranes. Highly lipid-soluble anesthetics generally have greater potency.

Difficulty: Medium Question 14 of 20

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