Which of the following is the most appropriate management for a patient with an INR of 8.0 but NO active bleeding?
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Correct answer: Irreversible acetylation of cyclooxygenase-1 (COX-1)
For high INR without bleeding, the recommended approach is to hold Warfarin and administer oral Vitamin K (Phytomenadione). This allows for a gradual and safe reduction of the INR without the risks associated with IV administration or blood products.
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