Which enzyme is targeted by Trimethoprim, the agent frequently combined with Sulfamethoxazole?
Show answer and explanation
Correct answer: Dihydrofolate reductase
Trimethoprim inhibits dihydrofolate reductase, which is the step following the sulfonamide target in the folic acid synthesis pathway. The combination of the two drugs results in sequential blockade and synergistic bactericidal activity.
Keep practicing
More Sulfonamides questions
- A patient with a Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is at risk for which complication when taking sulfonamides?
- Which sulfonamide is specifically used topically to prevent infections in patients with extensive second- and third-degree burns?
- What is the primary mechanism of resistance developed by bacteria against sulfonamides?
- Sulfonamides can cause the formation of crystals in the urine (crystalluria). Which patient instruction is essential to minimize this risk?
- Which of the following is a severe, potentially fatal hypersensitivity reaction associated with sulfonamides involving skin and mucous memb…
- Sulfonamides are contraindicated in newborns because they can displace bilirubin from albumin, leading to which neurological condition?