Which of the following is a common cardiovascular side effect associated with macrolide use, especially when combined with other CYP3A4 inhibitors?
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Correct answer: QT interval prolongation
Macrolides can block potassium channels in the heart, leading to delayed repolarization and QT interval prolongation. This increases the risk of the life-threatening polymorphic ventricular tachycardia known as Torsades de Pointes.
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