Resistance to macrolides often occurs via the methylation of the 23S rRNA binding site. This mechanism is mediated by which gene?
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Correct answer: erm
The erm (erythromycin ribosome methylation) gene encodes enzymes that methylate the adenine residue of the 23S rRNA. This modification reduces the affinity of macrolides, lincosamides, and streptogramin B for the ribosome (MLSb resistance).
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