Which macrolide is a potent inhibitor of the CYP3A4 enzyme system and is most likely to cause drug-drug interactions with statins or warfarin?
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Correct answer: Clarithromycin
Clarithromycin and Erythromycin are strong inhibitors of CYP3A4, whereas Azithromycin does not significantly inhibit this enzyme. Inhibition of CYP3A4 can lead to toxic accumulations of drugs that are substrates for this pathway.
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