Which pharmacokinetic interaction significantly reduces the oral bioavailability of fluoroquinolones?
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Correct answer: Chelation with multivalent cations (e.g., Al, Mg, Ca, Fe)
Fluoroquinolones form insoluble complexes with multivalent cations found in antacids, iron supplements, and dairy products. This chelation prevents the absorption of the drug, leading to therapeutic failure.
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