Which Cephalosporin can cause a disulfiram-like reaction when consumed with alcohol and may lead to vitamin K deficiency?
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Correct answer: Cefotetan
Cefotetan and Cefoperazone contain a methylthiotetrazole (MTT) side chain. This structure inhibits aldehyde dehydrogenase (causing the disulfiram reaction) and can interfere with vitamin K metabolism, increasing the risk of bleeding.
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