Which antifungal drug class inhibits ergosterol synthesis by blocking the enzyme lanosterol 14-alpha-demethylase?
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Correct answer: Azole antifungals
Azoles such as fluconazole and ketoconazole inhibit the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase. Ergosterol synthesis is blocked and the fungal cell membrane loses its integrity.
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