Which antifungal drug commonly causes nephrotoxicity as a major adverse effect?
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Correct answer: Amphotericin B
Amphotericin B also binds cholesterol in human cell membranes, and renal tubular cells are especially susceptible, so azotaemia, potassium wasting and magnesium wasting are common. Renal function and electrolytes must be monitored, and liposomal preparations reduce this toxicity.
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