Which pharmacokinetic property allows for 'once-daily dosing' of aminoglycosides despite their relatively short half-lives?
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Correct answer: Post-antibiotic effect
Aminoglycosides exhibit a significant Post-Antibiotic Effect, where bacterial growth remains suppressed even after the plasma concentration falls below the MIC. This, combined with concentration-dependent killing, supports the efficacy of large, infrequent doses.
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