The synergistic effect observed when combining an aminoglycoside with a cell-wall synthesis inhibitor (like Penicillin) is primarily due to:
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Correct answer: The beta-lactam increasing the permeability of the cell wall
Beta-lactams damage the peptidoglycan layer of the bacterial cell wall. This allows the large, polar aminoglycoside molecules to enter the cytoplasm more easily, where they can reach their ribosomal targets.
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