Aminoglycosides are known for their narrow therapeutic index. Which two major toxicities are most commonly associated with this class?
Show answer and explanation
Correct answer: Ototoxicity and Nephrotoxicity
Aminoglycosides accumulate in the endolymph of the ear and the proximal tubule cells of the kidney. This leads to progressive, often irreversible damage to cranial nerve VIII (vestibular and auditory) and reversible acute tubular necrosis.
Keep practicing
More Aminoglycosides questions
- Which aminoglycoside is the most commonly used for systemic infections and serves as the prototype for the class?
- The synergistic effect observed when combining an aminoglycoside with a cell-wall synthesis inhibitor (like Penicillin) is primarily due to:
- Which aminoglycoside is specifically indicated as a second-line treatment for Tuberculosis and was the first antibiotic effective against t…
- What is the most common mechanism by which bacteria develop resistance to aminoglycosides?
- Which of the following aminoglycosides is considered the 'least susceptible' to bacterial modifying enzymes and is often used for resistant…
- Neomycin is rarely administered parenterally due to extreme toxicity. What is its most common clinical use?