Which of the following aminoglycosides is considered the 'least susceptible' to bacterial modifying enzymes and is often used for resistant Gram-negative infections?
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Correct answer: Amikacin
Amikacin is a semisynthetic derivative of kanamycin with a side chain that protects it from many bacterial inactivating enzymes. Consequently, it often remains effective against strains that are resistant to gentamicin and tobramycin.
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