Which of the following describes the primary mechanism of action for aminoglycosides?
Show answer and explanation
Correct answer: Irreversible binding to the 30S ribosomal subunit, causing misreading of mRNA
Aminoglycosides bind irreversibly to the 30S ribosomal subunit. This interference leads to the inhibition of the initiation complex, misreading of the genetic code, and the production of nonfunctional proteins, resulting in bactericidal activity.
Keep practicing
More Aminoglycosides questions
- Why are aminoglycosides largely ineffective against obligate anaerobic bacteria?
- Which pharmacokinetic property allows for 'once-daily dosing' of aminoglycosides despite their relatively short half-lives?
- Aminoglycosides are known for their narrow therapeutic index. Which two major toxicities are most commonly associated with this class?
- Which aminoglycoside is the most commonly used for systemic infections and serves as the prototype for the class?
- The synergistic effect observed when combining an aminoglycoside with a cell-wall synthesis inhibitor (like Penicillin) is primarily due to:
- Which aminoglycoside is specifically indicated as a second-line treatment for Tuberculosis and was the first antibiotic effective against t…