Respiratory Pathology · Pathology

Which of the following is a key histological feature of Sarcoidosis?

  1. Caseating granulomas with acid-fast bacilli
  2. Non-caseating granulomas with Asteroid and Schaumann bodies
  3. Eosinophilic pneumonia with Charcot-Leyden crystals
  4. Necrotizing vasculitis and 'geographic' necrosis
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Correct answer: Non-caseating granulomas with Asteroid and Schaumann bodies

Sarcoidosis is a systemic disease characterized by non-caseating granulomas. Within the giant cells of these granulomas, one may find laminated calcium/protein inclusions (Schaumann bodies) or star-shaped inclusions (Asteroid bodies).

Difficulty: Medium Question 12 of 20

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