A pleural biopsy shows malignant cells forming glands and expressing Calretinin and WT-1. The background shows ferruginous bodies. What is the diagnosis?
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Correct answer: Malignant Mesothelioma
Mesothelioma is a tumor of the pleura strongly linked to asbestos exposure. Immunohistochemical markers like Calretinin and WT-1 are used to distinguish it from metastatic adenocarcinoma, which is usually negative for these markers.
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