What is the characteristic histological finding in 'Usual Interstitial Pneumonia' (UIP)?
Show answer and explanation
Correct answer: Spatial and temporal heterogeneity with fibroblastic foci
UIP, the pattern seen in Idiopathic Pulmonary Fibrosis, is defined by spatial and temporal heterogeneity. This means areas of normal lung exist alongside 'fibroblastic foci' (early lesions) and dense collagenous scarring (late lesions).
Keep practicing
More Respiratory Pathology questions
- Which condition is characterized by the permanent dilation of the airspaces distal to the terminal bronchioles without obvious fibrosis?
- A patient with 'Goodpasture Syndrome' will show which pattern on immunofluorescence of the lung biopsy?
- Which histological feature is the hallmark of the 'proliferative phase' of Diffuse Alveolar Damage (DAD)?
- A 55-year-old smoker presents with centriacinar emphysema. Which protease-antiprotease imbalance is primarily responsible for this tissue d…
- Which of the following is characteristic of the morphology of 'Curschmann spirals' found in the sputum of asthmatic patients?
- In the context of lobar pneumonia, which stage is characterized by an alveolus filled with fibrin, neutrophils, and disintegrated red blood…