Respiratory Pathology · Pathology

Which histological feature is the hallmark of the 'proliferative phase' of Diffuse Alveolar Damage (DAD)?

  1. Waxy hyaline membranes lining the alveolar ducts
  2. Type II pneumocyte hyperplasia and granulation tissue
  3. Dense intra-alveolar neutrophilic infiltrate
  4. Extensive interstitial fibrosis and honeycomb lung
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Correct answer: Type II pneumocyte hyperplasia and granulation tissue

Following the exudative phase characterized by hyaline membranes, the proliferative phase involves the repair of the alveolar lining via Type II pneumocyte hyperplasia and the organized growth of fibroblasts. This represents the lung's attempt to heal after acute injury.

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